Scientists introduce sugar-based method to enhance CAR-T cell storage and treatment potential

A team of scientists at MIT’s Koch Institute has created an alternative method for storing CAR-T cells that could simplify their use in cancer treatment. Traditionally, these cells depend on dimethyl sulfoxide (DMSO) for preservation, a chemical that must be removed before treatment—a process that restricts how widely hospitals can administer the therapy. The new technique replaces most of DMSO with sugars like trehalose and sucrose, eliminating the need for its removal while maintaining cell viability. Early tests in mice showed that cells preserved with sugars retained stronger effectiveness against tumors, including those in lymphoma and brain cancer models. The approach also demonstrated benefits for other cell types, such as mesenchymal stem cells, suggesting broader applications. By streamlining preservation, the method may lower barriers for clinics and expand access to this advanced treatment for patients in need. The research highlights a shift toward safer and more practical approaches in cell-based therapies, potentially reshaping how these treatments are delivered globally.